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Marshall J, Dolan BM, Garcia EP, Sathe S, Tang X, Mao Z, et al

Abstract Parkinsons disease (PD) is a chronic and progressive neurodegenerative disorder characterized by a complex pathophysiology and a range of symptoms

One vehicle-controlled study of combination brimonidine 0.33% gel with ivermectin 1% cream over a period of 12 weeks found that the combination treatment was significantly statistically superior to placebo and statistically significant to regimens that used brimonidine for a shorter period of time in conjunction with ivermectin.10 In addition to use with other topical pharmacological agents, oxymetazoline has been studied in combination with device therapy for rosacea

Some research questions specifically engage melanocortin pathway biology where KPV's mechanism is directly applicable