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More than 80-90% of total ROS are reportedly generated by mitochondrial electron chain Complexes I and III, and NADPH after oxidation by NOXs (NADPH oxidases) is another important source of O 2 - and H 2 O 2 producing-proteins in signal transduction[75, 76]
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Its expression was higher in tumors resistant or refractory to 1st-line chemotherapy compared with sensitive tumors [28]
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