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Hepatic metabolism research has examined Retatrutides influence on liver fat markers in pre-clinical models of non-alcoholic fatty liver disease, with studies exploring how combined GLP-1, GIP, and glucagon receptor activation affects hepatic lipid handling compared to dual-receptor compounds

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The published preclinical work (Neelakantan et al., referenced via PMC5826726) reported clean safety at 20 mg/kg subcutaneous in mice over 11 days

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However, doctors may investigate further when low B12 appears alongside symptoms that suggest a more serious underlying illness
