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VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome
The intracellular signaling pathways that mediate the actions of neurotrophic factors on synaptic connections, as well as neuronal survival and function include tyrosine kinase receptor activation of the kinases PI-3K-Akt and Raf-MEK-ERK 4648 (Figure 3)

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