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Experimentally, this problem can be tackled in several ways, the most common being: 1) RNAi knock-down or mutation of the genes encoding the enzymes of the pathway

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La sibutramina formaba parte de la composicin de medicamentos con receta destinados al tratamiento de la obesidad, sin embargo, se suspendi su comercializacin en la Unin Europea por asociarse su consumo a efectos adversos graves de tipo cardiovascular, tal como se refleja en la nota informativa de la AEMPS sobre sibutramina (Reductil), publicada el 21 de enero de 2010

McCown MF, Rajyaguru S, Kular S, Cammack N, Najera I (2009) GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796