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Another RCT found a decrease in homocysteine with 1000 g hydroxo-B12 monthly for 3 months by 2 mol/l, whilst the control group had a 2 mol/l increase, although the difference was not statistically significant

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The compounds have been found in dietary supplements and products marked as "research only", creating exposure risk for athletes who may purchase such products for cognitive benefits without understanding they're consuming prohibited substances with no established safety profile

Many individuals who incorporate energy and fat-burning supplements or a B12 metabolism booster report improved motivation