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doi: 10.1016/j.schres.2007.09.030

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Multi-omics analysis further revealed that GRC modulated metabolic and proteomic networks associated with immune regulation and ferroptosis, confirming that its therapeutic benefits were mediated through suppression of the CaMKII/HO-1/GPX4 axis

When an overexpression of Bach-1 occurs, as in high oxidative stress, it competes with Nrf2 to heterodimerize with small Maf proteins, repressing ARE-mediated gene expression [195]

Central to these adaptations is the shift from ammonia- and urea-based nitrogen excretion (common in amphibians) to uric acid production, a metabolic adaptation that dramatically reduces obligatory water loss