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Systemic effects of long-term, higher-dose ICS: Adrenal suppression Decreased bone mineral density Increased risk of cataracts and glaucoma Oral corticosteroid systemic effects (more severe, especially with prolonged use): Osteoporosis, diabetes, hypertension, weight gain, mood changes Drug Interactions Theophylline is metabolized by the cytochrome P450 system (primarily CYP1A2), making it susceptible to many interactions: Ciprofloxacin inhibits CYP1A2 increases theophylline levels (toxicity risk) Rifampin induces CYP enzymes decreases theophylline levels (reduced efficacy) Beta-2 agonists and beta-blockers work in direct opposition

[DOI] [PubMed] [Google Scholar] 203.Maurer I., Zierz S., Mller H

Glutathione is a powerful antioxidant naturally produced in the liver and cells, composed of three amino acids: glutamine, glycine, and cysteine

To view a copy of this licence, visit About this article Cite this article Srivastava, A., Vinod, P.K

These are usually not essential unless the body contains illness or stress