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Video Review: Longitudinal Studies Block 1, Question 12 Explanation Correct Answer: D

One notable point is that as a late-phase cytokine, the increase of HMGB1 release is tightly associated with increased mortality in animal models of sepsis (23, 3537)
Serum leptin and active ghrelin concentrations were measured using commercial radioimmunoassay (RIA) kits, following the manufacturers instructions

The frequency of grade 3 and 4 toxicities that occurred during therapy was similar between the randomized groups, and there was no difference in cumulative incidence of second malignant neoplasms