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found that TMAO can inhibit the RCT process and affect cholesterol metabolism ( ApoE / mice, and further activate the nuclear receptors farnesoid-X-receptor (FXR) and small heterodimer partner (SHP), to reduce the expression of cholesterol 7-hydroxylase (Cyp7a1) to inhibit bile acid synthesis, thus accelerating the formation of atherosclerosis (82)
Defects in the OCTN2 gene cause primary carnitine deficiency, further emphasizing the strategic position of OCTN2 in maintaining carnitine homeostasis [165]
A 2024 case series in Journal of Clinical Endocrinology reported that patients receiving combination therapy showed 18% greater fat mass reduction compared to GLP-1 monotherapy, with improved energy scores on validated fatigue assessments (Morrison et al., 2024)
Effects of added dietary fiber and rearing system on the gut microbial diversity and gut health of chickens
Role of Oxidative Stress in the Pathogenesis of Non-alcoholic Fatty Liver Disease: Implications for Prevention and Therapy
