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10.3389/fgene.2020.00928 139 HadanoS.OtomoA.KunitaR.Suzuki-UtsunomiyaK.AkatsukaA.KoikeM.et al

Maxon, J

6.3 ALA Alpha-lipoic acid (ALA) is a disulfide compound with unique biochemical properties: it is both water- and fat-soluble, enabling it to act throughout the cell, and it can counteract excessive ROS induced by chronic hypoxia by neutralizing free radicals, chelating metal ions, and regenerating other antioxidant substances (such as vitamins C and E and glutathione)

Experimental studies have shown that while excessive statin treatment can impair oligodendrocyte maturation (Paintlia et al., 2005), modulation of cholesterol metabolism may reduce oxysterol toxicity while preserving glial function

GSH is present at very high concentrations (110 mM) in humans, allowing it to scavenge ROS either directly or indirectly [15]