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The SIRT1 promotes the deactivation and activation of coactivator one alpha, the primary regulator of mitochondrial biogenesis [72]

[DOI] [PMC free article] [PubMed] [Google Scholar] 119.Ulloque-Badaracco J.R., Hernandez-Bustamante E.A., Alarcon-Braga E.A., Al-Kassab-Crdova A., Cabrera-Guzmn J.C., Herrera-Aazco P., Benites-Zapata V.A

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1C), suggesting that tumor mitochondria are in greater need of antioxidative protection

Furthermore, certain chelators can disrupt iron-dependent neurophysiological processes, thereby further constraining their clinical applicability in NDDs (Marupudi and Xiong, 2024)