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While our efforts to define the endogenous ligand for NHR-49 were unsuccessful, mutating the ligand-binding pocket might allow us to determine the role of ligand binding in the transcriptional activity of NHR-49

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[19] Fragile X syndrome: A 2015 Cochrane review of ALCAR in fragile X syndrome found only two placebo-controlled trials, each of low quality, and concluded that ALCAR is unlikely to improve intellectual functioning or hyperactive behavior in children with this condition

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