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These are neurotoxin induction-based models (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 6-hydroxydopamine (6-OHDA) and agricultural pesticides (rotenone, paraquat)), pharmacological models (reserpine or haloperidol treated rats), and genetic models (-synuclein, leucine-rich repeat kinase 2 (LRRK2), DJ-1, phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK-1) and Parkin)

B-12 Shots for Boosting Mood Because B-12 is important for healthy nerve functioning and in metabolizing serotonin, the chemical that helps to regulate our mood, being deficient in B-12 can lead to depression

Less than 1% of people with B12 deficiency report getting optic neuropathy

Treatment depends on the cause and the severity of deficiency