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Supplementary material The Supplementary Material for this article can be found online at: Supplementary Table 1 The chemical component list of Xiaojin Pill

Together, these preclinical assessments indicated minimal to no risk of immunogenicity in clinical studies

This triggers a cascade of effects: accelerated keratinocyte proliferation, increased desquamation (shedding of the outer layer), and stimulation of collagen synthesis in the dermis

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It is hypothesized to be linked to excessive MMP-1 activity, which could temporarily break down existing collagen faster than new collagen is built