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60,61,62 RNase H-dependent ASOs, such as gapmers, bind to complementary mRNA, recruit RNase H to cleave mRNA, and thus block translation of the target gene
The combined treatment modality resulted in the most pronounced overall enhancements, suggesting additive anti-inflammatory properties
Think of it as UV maintenance between sun protection applications---helpful for preventing cumulative tanning from everyday brief sun exposure
CNS Glucose Metabolism in Amyotrophic Lateral Sclerosis: A Therapeutic Target? Cell & Bioscience 11: 14
2021;5:e10405
