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During the Dose Optimization Period, subjects were titrated until an optimal dose, based on tolerability and investigator's judgment, was reached

Using Ca 2+ fluorescence measurements, the Ca 2+ -transient duration, amplitude, and area under the curve were all significantly increased in the presence of 100 M TMAO (Figures 8AD), consistent with the increase in the Ca 2+ current observed in Figures 6, 7

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