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In some studies, based on the intraperitoneal infusion of LPS in mice models, it was observed an increase in pro-inflammatory cytokines, such as IL8 and TNF alfa, but also the appearance of autoantibodies against ox LDL, the accumulation of inflammatory infiltrate in the vascular intima, and an increasing aortic atherosclerosis [64]

For patients who experience a sustained increase in resting heart rate while taking semaglutide, the drug should be discontinued

Studied for metabolic regulation and appetite research

Abbreviations AD: Alzheimers Disease APP: Amyloid precursor protein HECE: Hydro-ethanolic leaf extract of Colocasia esculenta L

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