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Metabolic reprogramming in macrophages and dendritic cells in innate immunity

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4.2 Mitochondrial dysfunction Mitochondria are another important internal source of ROS in sperm cells

While Casp1 (which was the most highly upregulated gene when comparing mock-infected sensitized urothelia to resolved (Supplementary Table 2)) and other pyroptosis-related genes (including Aim2 , Gsdmc2 and Gsdmc3 ) were upregulated in sensitized differentiated urothelia, other pyroptosis-related genes (such as the Naips ) as well as apoptosis and necroptosis-related genes were upregulated in resolved differentiated urothelia, suggesting that resolved and sensitized cells are predisposed to different PCD mechanisms during UPEC infection