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Full results may take 12 months or longer, since peptides take time to work through cumulative cellular effects

The primary endpointchange in Clinical Dementia Rating Sum of Boxes (CDR-SB)showed no significant difference between groups

Dianzani MUl: 4-Hydroxynonenal and cell signaling

Existing intervention trials are limited by short duration, small sample sizes, heterogeneity in formulations and dosing, and a reliance on surrogate biochemical endpoints rather than hard clinical outcomes ( Consequently, while magnesium repletion represents a biologically plausible adjunctive strategy, its clinical utility in ALD requires validation in rigorously designed, long-term randomized controlled trials