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These extremely rare side effects include: Reactive thrombocytosis during the first week of use in megaloblastic anaemia Hypersensitivity reactions including: rash, itching, exanthema, antibodies to HYDR0XOCOBALAMIN-transcobalamin II Anaphylaxis Hypokalaemia Headache, paraesthesia, tremor Irregular heartbeat (arrhythmias secondary to hypokalaemia) Nausea Vomiting Diarrhoea Fever, chills, hot flushes, dizziness, malaise, pain and / or swelling at the injection site Acne Abnormal colouration of the urine (chromaturia) What should you not do after a B12 shot

And, clearly, there are shortcomings to the current drug-approval process

You can see you must make a conscious effort to keep all Vitamin B levels within a healthy range consistently in order to avoid any long-term illness

Further investigation demonstrated that lactate administration in mice induced hepcidin expression, leading to reduced FPN levels

Despite its growing popularity among athletes and its wide availability through non-regulated sources, there is minimal human data available. Vasireddi et al., American Journal of Sports Medicine, 2025 This gap matters
