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Cellular antioxidant Functions As the most effective aqueous antioxidant in plasma, interstitial fluids, and soluble phases of cells, ascorbate appears to be the first line of defense against ROS( reactive oxygen species-oxygen based oxidizers) arising in those compartments

Other pathological changes include increased ROS production, enhanced monocyte migration across the endothelium, altered glucose transporter protein-1 expression, reduced tight junction proteins (occludin and zonula occludens-1) and activation of myosin light chain kinase (MLCK) in BMVECs [117-119]

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