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Mingmei Zhou, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Embryos were washed with hybridization buffer at 65 C for 30 min, followed by digestion with RNaseA at 37 C for 30 min