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Description
The reduced Cu + directly binds to lipoylated proteins (e.g., DLAT) in the TCA cycle, causing abnormal oligomerization and aggregation, which ultimately leads to serious proteotoxic stress
J.HgmanM.OlinA.-C.et al (2017)
Int J Dev Neurosci 9: 175180
Nature 593 (7860), 575579 (2021)
Il vite leur accumulation et rduit donc les ractions dltres
