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The increased risk may relate to rapid weight loss, changes in gallbladder motility, or alterations in bile acid composition

doi: 10.1016/j.exer.2005.01.012

The rare individual who might consider this combination needs exceptional GI tolerance proven on prior GLP-1s, physician supervision with frequent monitoring, ability to afford $15,000-30,000 annually, understanding they're experimenting on themselves, and willingness to stop immediately if severe side effects emerge

In a recent investigation undertaken by our group, adult mice with partial IGF-1 showed a decrease in the expression of genes involved in glucose metabolism (phosphoenolpyruvate carboxylase-1, glucose-6-phosphatase, pyruvate dehydrogenase kinase isoenzyme-4, and ATP-citrate lyase), resulting serious hyperglycaemia [164]

Two of my best friends of 30 years both had the Pfizer vaccine and both of them have also had weird periods so Im sure this is not an uncommon symptom despite the lack of information about it