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Peroxynitrite is believed to inhibit electron flow at CI, CIII, and minimally at CIV via direct interaction with the complexes ( Furthermore, increased free radical production can also induce cell death via the downstream effects of oxidative damage to the respiratory chain and RNS-mediated induction of diminished mitochondrial permeability transition ( Alternatively, RNS-mediated induction of mitochondrial permeability transition may also signal (necrotic or apoptotic) cell death ( There is no doubt that NO plays a key role in the redox state

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tuberculosis , pathogenesis, immune evasion, vaccine Citation Yang H, Lei X, Chai S, Su G and Du L (2024) From pathogenesis to antigens: the key to shaping the future of TB vaccines