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HGF is the only ligand for the tyrosine kinase receptor encoded by the MET proto-oncogene (Naldini et al., 1991)
also show that MOTS-c administration also prevents ovariectomy-induced obesity and insulin resistance in mice via the AMPK pathway
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Vander Jagt DL, Kolb NS, Vander Jagt TJ, Chino J, Martinez FJ, Hunsaker LA, Royer RE: Substrate specificity of human aldose reductase: identification of 4-hydroxynonenal as an endogenous substrate
