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Proinflammatory cytokines can significantly reduce serotonin (5-HT) and dopamine (DA) levels by increasing the expression of monoamine reuptake transporters and decreasing the availability of essential cofactors required for monoamine synthesis through the p38 MAPK pathway (Huang et al., 2025)

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As we continue to unravel the complexities of astrocytic metabolism, these cells may emerge as crucial targets for interventions aimed at maintaining brain health and combating neurodegenerative diseases

A prospective randomized controlled trial comparing infliximab and etanercept in patients with moderate-to-severe chronic plaque-type psoriasis: the Psoriasis Infliximab vs

KPV modulates the immune response rather than suppressing it