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doi: 10.1038/s41586-020-2095-1 117 QiY

The intracellular concentration of carnitine ranges from 1 to 5 mM, while the concentration in the plasma ranges from 25 to 50 M (Nezu et al., 1999)

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In particular, further research is needed to establish clear recommendations for their use in PCOS managemens, including which patients would benefict most, when to start treatment, the optimal duration of therapy, the specific effectiveness of statins in PCOS and the potential beneficts of combining statins with other treatments.This is a priority, since dyslipidemia is the most prevalent CV risk factor in women with PCOS, that is a high risk disease for CV events for the high prevalence of other CV risk factors such as obesity, hypertension, and diabetes