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The primary Phase II reactions are: Glucuronide conjugation most important reaction (detailed below) Sulfate conjugation important reaction (detailed below) Acetylation Amino acid conjugation Glutathione conjugation Methylation Glucuronide Conjugation Glucuronide conjugation is one of the most important and common Phase II reactions

The spectral range for analysis was set to 0.24.2 ppm, and the Cramer-Rao bounds for GSH mPFC were 10 3% (mean s.d.)

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This is because the carboxylate groups of these acyl-CoA molecules can undergo endogenous nucleophilic attack on the thioester bond of coenzyme A, resulting in the formation of a cyclic anhydride that is more reactive than the parent acyl-CoA, thereby facilitating a more effective non-enzymatic modification of proteins