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NF-B is a key regulator of pro-inflammatory cytokines including IL-6, IL-8, and others which contributes to the development of chronic inflammation (Isral, 2010)

Lipid peroxidation leads to damage to cell membranes and mitochondria, which in turn results in cellular dysfunction and muscle atrophy

Key susceptibility genes are involved in pathways such as mucin production, surfactant metabolism, telomere maintenance, immune regulation, and epithelial integrity [20]

Leitao, E

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