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The following section will discuss the design of such microorganisms, their mechanisms of action, and the outcomes of preclinical studies

164 In a randomized crossover trial in 50 subjects with male infertility, one month of treatment with a supplement containing pine bark extract plus L-arginine (an amino acid precursor to nitric oxide which regulates blood vessel function) increased semen volume, sperm number and concentration, motility, and vitality, and improved sperm morphology compared with placebo

doi: 10.1038/s41467-017-02325-2 8

For example, the peak at 1.456 THz of L-2HG was caused by rotation of the propyl group (Figures 2a3), while the torsion and vibration of the ring affected by the butyrate group formed the peak at 1.695 THz (Figures 2b3)