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However, long-term human safety trials are lacking, so usage should be approached with caution
Whey proteins contain sulfur-containing amino acids such as cysteine (Cys)
Tanguay et al., 2021

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However, the F-statistic prioritizes sites with large overall DNAm differences across all cell types, which can lead to the over-selection of CpGs that strongly differentiate one or a few cell types while neglecting others, resulting in imbalanced discriminatory power within the panel
