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Since peptides, proteins, and hormones can directly reach the brain when administered intranasally via transport and diffusion along the olfactory and trigeminal nerves [241], future studies should explore whether intranasal melatonin could be a viable therapeutic option for increasing brain melatonin levels in individuals at risk of developing AD

A minority were recruited via patient self-referrals (0.4%) or staff referrals (0.7%)

Implementation of a longitudinal project would provide a more nuanced understanding of how oxidative stress and biopsychosocial factors interplay over time

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Most patients begin to notice changes in body composition, energy, or recovery within 46 weeks, though optimal results are typically seen after 812 weeks of consistent use, alongside healthy lifestyle habits