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Specifically, caffeic acid has shown neuroprotective properties and is a component of a patented mixture of flavonoid compounds, known as Pycnogenol (PYC), which has produced very promising results in rat models of TBI [58, 68]
Theranostics 13 , 27572773 (2023)
Though there currently lacks questionnaires differentiating mechanisms causing different subtypes of nociplastic pains (i.e., topdown or bottomup) [12], ongoing efforts have been made to establish and evaluate the types and combinations of features effective in distinguishing nociplastic pains of different mechanisms [209, 218, 265, 271]
Based on individual needs, advanced tests such as sperm DNA fragmentation, scrotal ultrasound or microbiome evaluation may be recommended to identify hidden causes affecting fertility
It means they should approach those goals carefully, with proper medical screening, realistic expectations, and professional guidance
