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The brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B (TrkB), are essential and common mechanisms for the antidepressant effects of both the parent molecules of ketamines [i.e., S, R()ketamine, S(+)ketamine, and R()ketamine] and their active metabolites [i.e., (2R,6R)-hydroxynorketamine and of S(+)norketamine] (Yang et al., 2019)

10.1016/j.atherosclerosis.2013.10.029 Atherosclerosis 98 RousselJ.ThireauJ.BrennerC.SaintN.ScheuermannV.LacampagneA.et al (2015)
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This deficiency can lead to symptoms including fatigue, brain fog, constipation, digestive issues, and muscle weakness/aches

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