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Consistent with this idea, acute and chronic injury in TBI is associated with activation of calcium-dependent cysteine proteases such as calpain-2, which is induced by high levels of intracellular calcium (Liu et al., 2014

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A major underlying problem may also be indicated by symptoms such as heavy menstrual bleeding, dizziness, persistent exhaustion, weakness, pink, red, or dark blood in the urine or stool, or trouble stopping bleeding after an injury

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