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Deletion of the LGR4 gene in skin epithelial cells inhibits the activation of canonical Wnt signalling in hair follicles, manifesting as a significant reduction in the expression of -catenin, c-Myc, AXIN2, and LEF-1, inhibiting the activation of HFSCs and delaying the growth phase

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In this context, the histological grading, mitotic count, a high expression of Ki-67, KIT pattern 3, and ITD in exon 11 of KIT stood out

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