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To investigate whether GCG, VGF, SCG2, SCG3, and CHGA contribute to hyperglucagonemia in individuals with diabetes and diabetic mice, we examined gene expression data from cells in patients with type 2 diabetes (GSE84133) 42 and high-fat diet (HFD)-induced obese mice (GSE203151) 43

Critical subgroups at high B12 deficiency risk: patients on metformin (the most prescribed diabetes drug, which blocks B12 absorption in the gut up to 30% of long-term metformin users become B12 deficient)

The entire data set, covering an overall mass ( m/z ) and TW CCS N2 range of m/z 146862 and 120280 2 respectively, was utilized to compare mean measured ( TW CCS N2, meas ) with predicted CCS ( TW CCS N2, pred ) values (see Correlation between TW CCS N2, pred and mean TW CCS N2, meas values)

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