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Description
Assays performed using a fully complementary target RNA and an AGO2 active-site variant (D669A, to prevent slicing of fully complementary target RNA) showed weak binding to ZSWIM8 and polyubiquitylation activity intermediate between that of the seed-only and trigger RNAs (Extended Data Fig

Um, I would say if you wanted to play devil's advocate, the big thing is long-term safety, right
This usually resolves on its own within a few days
biological effects of magnetic water on human and animals

10.1021/acssynbio.7b00265