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Because Gly675 is located at the bottom of a wall of the S1 subsite (Fig
PMID 2240884

DA neurons derived from these lines were assessed for -syn aggregation under normal and preformed fibril (PFF) treatment conditions, revealing gene-dosage-dependent increase in aggregation, with the quadruple copy of SNCA DA neurons (4 SNCA ) showing the highest vulnerability 29

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[17] Naturally occurring lipoic acid is always covalently bound and not readily available from dietary sources
