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Incretin-based therapies have been associated with a body weight (BW) reduction of 5% in at least half of patients in most randomized controlled trials (RCT) and real-world studies (RWS)

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Furthermore, under inflammatory conditions, AD-MSCs display more pronounced proliferation enhancement and simultaneous chondrogenic inhibition compared to amniotic fluid-derived MSCs (AMSCs) ( Besides cytokines, matrix metalloproteinases (MMPs) also play a key role in the inflammatory microenvironment