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CVID-associated TACI mutations affect autoreactive B cell selection and activation

CrossRef Analysis of the Clinicopathological Characteristics of Gastric Cancer in Extremely Old Patients Il Woong Sohn, Da Hyun Jung, Jie-Hyun Kim, Hyun Soo Chung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee Cancer Research and Treatment.2017

Recent studies utilizing CRISPR screens and Perturb-map analysis have identified IL-4 as a key mediator of immune resistance, particularly in its ability to sustain an immunosuppressive niche that limits effector T cell activity

This leads to an increase in intracellular ferrous iron content, making the cells more susceptible to ferroptosis

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