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A total of nine functional MRP genes have been identified ( MRP1/ABCC1 to MRP9/ABCC9 ), although the physiological functions of many MRPs remain undefined (Borst and Oude Elferink, 2002

ATP insufficiency also adversely affects neuronal function by disrupting Ca + regulation, impairing synaptic activity and neurotransmitter synthesis (7880)., and activating the AMPK-mTOR pathway to inhibit protein synthesis and cellular repair (81, 82)

Relevant biosynthetic and metabolic pathways associated with GSH
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For example, dysbiosis of the esophageal/intestinal microbiome and elevation of peripheral blood LPS can regulate ferroptosis in the esophageal epithelium by increasing ACSL4 expression, serum ferritin secretion, and iron accumulation [95]
