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In addition, the absence of any detectable increase in cellular GSSG contents in treated astrocytes demonstrates that the presence of itaconate, DI or OI does not cause any detectable oxidative stress under the conditions used

& Eggersdorfer, M

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However, our data suggest that following GSH depletion, NRF2 is stabilized, and this stabilization is associated with decreased expression of lipogenic enzymes and lower serum triglyceride levels

doi: 10.1089/rej.2008.0716 245 MiottoGRossettoMDi PaoloMLOrianLVenerandoRRoveriAet al