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The global economic burden is substantial, with annual costs estimated at $20 - 30 billion, including $10 billion in direct healthcare costs and $15 - 20 billion in productivity losses due to disability (5)

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This imbalance occurs when antioxidants are insufficient to effectively neutralize reactive oxygen species (ROS) and reactive nitrogen species (RNS) in a timely fashion, leading to the buildup of free radicals

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Human bone marrow mesenchymal stromal/stem cells regulate the proinflammatory response of monocytes and myeloid dendritic cells from patients with rheumatoid arthritis