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Notably, urolithins demonstrated cytotoxic effects at concentrations near their CYP1B1 inhibitory IC50 values
Thus, germ cells have a modified androgen/estrogen ratio, and while testosterone regulates testicular functions, estrogens also regulate gonadotropin secretion, Leydig cell development, steroidogenesis, and spermatogenesis and spermiogenesis in some mammals 73
The course of BD is complicated by some of these disorders, including AUD [102], anxiety [103], and ASD [104], which implies a potential intersection of their pathogenesis at ferroptosis
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This model is valuable for targeted drugs screening to treat dormant LSCs in the microenvironment
