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247 Besides, ROS oxidize PTP1B, inhibiting its phosphatase activity and thereby preventing dephosphorylation of signaling components such as the IL-4 receptor, which prolongs STAT signaling 248 (Table 1, Fig

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Baroncelli L, Braschi C, Spolidoro M, Begenisic T, Sale A, Maffei L

The capability of Sp to replenish reduced glutathione levels was further tested in neuronal cells exposed to MPP + , the toxic bioactivation product of MPTP known to induce Parkinsonian phenotype in animal models 1