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Author Contributions Conceptualization was contributed by EC, SM, MD, AD, TC, DL, GC, CL, VM, RG, FP, FCo, KA, and LB
Finally, homology models of mammalian ABC proteins based on structures of bacterial ABC transporters indicate that the coupling of substrate translocation through the MSDs to the ATPase (catalytic) activity of the NBDs is mediated by the CLs at the interfaces between the two domains (36)
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