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Stress can lead to changes in gastric physiology, such as heightened gastric acid secretion, diminished mucosal blood flow, and impaired mucosal defense mechanisms, all of which contribute to the formation of ulcers

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Numerous studies have revealed the complexity and diversity of the Nrf2-Keap1 pathway in regulating biological processes, including cell proliferation, differentiation, anti-inflammation, and cytoprotection (Murakami and Motohashi, 2015

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3,4 Thus, the systemic Cu levels must be maintained within a narrow range to ensure normal biochemical processes